In 2006, Cartoon Network produced a live-action/animated hybrid TV-movie, Re-Animated, and while that didn't exactly remind folks of something a little more cerebral, like, say, "Who Framed Roger Rabbit?", which CN has aired in the past, it did prompt a spin-off.
However, Out of Jimmy's Head fell victim to the writer's strike in 2008, and ended up cancelled after its one and only season. Give CN credit for trying something different, and going with a relatively unknown cast, with the only "name" belonging to former ESPN anchor turned actor/game show host Bil Dwyer, whose previous gig was the short lived game, Dirty Rotten Cheaters. Insert your own jokes if needed. Anyway, Jimmy's Head belonged on TBS, not CN, but then, the Turner networks don't know anything about common sense programming.
Here's the intro:
Today, it's safely tucked away in the Turner/WB vaults.