History tells us that Ruff & Reddy was Hanna-Barbera's 1st series after breaking away from MGM. The dog & cat combo appeared in primetime on NBC for 3 seasons (1957-60), and the serialized format of their adventures was duplicated by Jay Ward, not once but twice (Rocky & His Friends & Hoppity Hooper), and others, such as Cambria (Space Angel & Clutch Cargo).
Ruff (Don Messick, who also narrated) was the cat, and Reddy (Daws Butler, using the same voice he'd use for Huckleberry Hound) was a bulldog. Somehow, I had envisioned Reddy having a stronger, tougher voice, but what did I know?
My first exposure to Ruff & Reddy was a brief---and I do mean, brief---cable run in the late 80's-early 90's, well before the introduction of Cartoon Network. Most unenlightened types might think Ruff & Reddy was a rip-off of Rocky & His Friends, due largely to the serial format, but the truth is, Ruff & Reddy came first by 2 full years.
The fact that CN & Boomerang have repeatedly ignored the series should tell you something about the lack of interest in H-B's storied history at those networks. Their loss, as usual.
Here's the opener, "Planet Pirates":
No rating. I didn't see enough of these shorts back in the day to form a credible opinion.