Rude Dog & The Dweebs has the distinction of being the last series Marvel sold to CBS, back in 1989. Ever hear of going out with a bang? I'd say Marvel's last CBS entry went in and out with a whimper.
Rude Dog (Rob Paulsen) shares an apartment with the 7 Dweebs, and regularly has to deal with an evil cat named Seymour. Hey, I don't make this stuff up. Additional talent includes Peter Cullen, Frank Welker, and Dave Coulier (The Real Ghostbusters, Full House).
If Marvel was aiming at a canine-driven clone of Hanna-Barbera's Top Cat, which also ran for 1 1st run season, it failed. Badly. Rude Dog was designed largely to promote a clothing line, not toys, which might have made things a little too upscale for the target demographic.
Here's the intro, narrated in character by Paulsen.
Episodes are available on YouTube, but not in full-screen for obvious reasons. From what we could see, this show should never have gotten out of the kennel.