On Saturdays, Dr. Robotnik (Long John Baldry) has already taken over the planet Mobius. Adventures of Sonic the Hedgehog, then, can be considered a sort-of prequel, as Robotnik has yet to succeed, and is routinely thwarted by Sonic (Jaleel White, Family Matters) and his best buddy/sidekick, Tails.
There were also short Sonic Sez messages at the end of each of the 65 daily episodes, which also set it apart from the Saturday show. After the syndication run ended, this series aired on cable on USA, then Toon Disney (now DisneyXD), before landing on This TV and Netflix.
Let's take a look at the opener: