Disney made a franchise out of 1989's "Honey, I Shrunk the Kids". Two sequels, one of which was direct-to-video, ultimately gave way to a weekly syndicated series.
However, the studio couldn't convince Rick Moranis ("Ghostbusters", ex-SCTV) to return to series television, so they hired Peter Scolari (ex-Newhart, Bosom Buddies) to take over the role of eccentric scientist and family man Wayne Szalinski, who ends up putting his family in one nutty sitch after another. Apparently, the change in actors didn't bother the franchise, Honey, I Shrunk the Kids lasted three seasons.
Here is a season 2 episode, "She's Like a Fish Out of Water".
Too bad Disney insists on leaving this in the vaults, as this would fit in nicely on Disney Channel and/or DisneyXD or ABC Family today.