UPN's loss ultimately became a boon for [adult swim].
Home Movies lasted barely more than a month on UPN in 1999, as the network had little patience when it came to ratings, especially for animated series. 2 years later, Cartoon Network acquired the show, and ran the complete 1st season on [adult swim]. The ratings got better, and 3 additional seasons were produced between 2001-4.
Whereas the first season was produced using the Squigglevision process created for Comedy Central's Dr. Katz, Occupational Therapist, and the ABC Saturday morning series, Science Court, the series changed animation houses for season 2 and switched to flash animation, which improved the quality of the show. Comic Paula Poundstone (Science Court) didn't return when production resumed for season 1, and the only other familiar name in the cast has become famous in his own right, H. Jon Benjamin (Archer, Bob's Burgers).
Here's the series opener, courtesy of Hulu: